Total neoadjuvant therapy for locally advanced rectal cancer in developing countries : about an observation in a private congolese clinic.

Auteurs

  • Elisée Mbayo Nsenga Ilunga Medical Oncology Unit, University Clinics of Lubumbashi, DR Congo; Division of Internal Medicine, University Clinics of Lubumbashi, DR Congo
  • Christian Kakisingi Ngama Division of Internal Medicine, University Clinics of Lubumbashi, DR Congo
  • Didier Malamba Lez Division of Internal Medicine, University Clinics of Lubumbashi, DR Congo
  • Willy Arung Kalau Division of Surgery, University Clinics of Lubumbashi, DR Congo; Surgery Department, Ars/Lubumbashi Clinic, Lubumbashi, DR Congo
  • Claude Mwamba Mulumba Division of Internal Medicine, University Clinics of Lubumbashi, DR Congo

Mots-clés :

locally advanced rectal cancer, otal neoadjuvant therapyt, OPRA

Résumé

Locally advanced rectal cancer has benefited and continues to benefit from considerable advances in terms of therapeutic management. Total neoadjuvant therapy has shown benefit over radiotherapy alone or with concomitant chemotherapy in many respects. The case presented and discussed here is that of a Congolese patient diagnosed with locally advanced rectal adenocarcinoma managed by the OPRA regimen with induction chemotherapy who completed his neoadjuvant therapy alternately in his country of origin and abroad despite some toxic effects noted. The management of this case illustrates the possibility of allowing patients from developing countries to benefit from therapeutic advances in the management of cancer disease despite the significant challenges.

 

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Références

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. juill 2017;28:iv22‑40.

Liu Z, Meng X, Zhang H, Li Z, Liu J, Sun K, et al. Predicting distant metastasis and chemotherapy benefit in locally advanced rectal cancer. Nat Commun. déc 2020;11(1):4308.

De Felice F, Crocetti D, Petrucciani N, Belgioia L, Sapienza P, Bulzonetti N, et al. Treatment in locally advanced rectal cancer: a machine learning bibliometric analysis. Ther Adv Gastroenterol. janv 2021;14:175628482110421.

Garcia-Aguilar J, Patil S, Gollub MJ, Kim JK, Yuval JB, Thompson HM, et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J Clin Oncol. 10 août 2022;40(23):2546‑56.

Verheij FS, Omer DMR, Williams H, Buckley JT, Lin ST, Qin LX, et al. Sustained organ preservation in patients with rectal cancer treated with total neoadjuvant therapy: Long-term results of the OPRA trial. J Clin Oncol. 1 juin 2023;41(16_suppl):3520‑3520.

Fokas E, Allgäuer M, Polat B, Klautke G, Grabenbauer GG, Fietkau R, et al. Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12. J Clin Oncol. 1 déc 2019;37(34):3212‑22.

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Publiée

04-02-2025

Comment citer

Elisée Mbayo Nsenga Ilunga, Christian Kakisingi Ngama, Didier Malamba Lez, Willy Arung Kalau, & Claude Mwamba Mulumba. (2025). Total neoadjuvant therapy for locally advanced rectal cancer in developing countries : about an observation in a private congolese clinic. Revue Africaine De Médecine Et De Santé Publique, 8(1), 55–60. Consulté à l’adresse http://rams-journal.com/index.php/RAMS/article/view/429

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