Etat de lieu de la diarrhée à rotavirus 2 ans après introduction du vaccin antirotavirus à Lubumbashi
Mots-clés :
diarrhée, rotavirus, vaccination, impact, génotype, LubumbashiRésumé
Introduction : La République démocratique du Congo (RDC) est l’un des pays où le taux de mortalité à rotavirus est le plus élevé au monde. Le but de cette étude était de décrire l’impact de la vaccination antirotavirus sur l’épidémiologie, la Clinique et le génotype de la diarrhée à rotavirus dans la ville de Lubumbashi, en RDC.
Méthodologie : nous avons mené une étude d’observation descriptive transversale menée sur 2 ans ayant concerné les enfants âgés de moins de 5 ans, hospitalisés pour diarrhée aigue à rotavirus dans le centre de contrôle de l’infection à rotavirus du Haut-Katanga.
Résultats : Au total, 116 enfants (55,90 % de garçons ; n =66) ont été étudiés entre 2020 et 2022. La plupart des enfants infectés par le rotavirus étaient : âgés ≤ 1 ans (69,83 %), vaccinés (97,41%), hospitalisés au urgence, presentais ≤ 5/jours la diarrhée (55,17%) et les vomissement (82,76 %). Les génotypes les plus communément retrouvés étaient le P[8] et le P[6] pour le VP4 et le G1 et G12 pour le VP7.
Conclusion : La vaccination antirotavirus a un impact positif sur l’épidémiologie, la clinique et le profil génétique de la diarrhée a rotavirus.il demeure important de continuer cette surveillance pour mieux appréander les changements après vaccination.
Téléchargements
Références
who et unicef. Progress on Sanitation and Drinking Water : 2015 Update and MDG Assessment. World Health Organization; 2015. 90 p.
Negesse Y, Taddese AA, Negesse A, Ayele TA. Trends and determinants of diarrhea among under-five children in Ethiopia: cross-sectional study: multivariate decomposition and multilevel analysis based on Bayesian approach evidenced by EDHS 2000–2016 data. BMC Public Health. 22 janv 2021;21:193.
GBD 2017 Diarrhoeal Disease Collaborators. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. Lancet Infect Dis. janv 2020;20(1):37‑59.
acute-diarrhea-french-2012.pdf [Internet]. [cité 6 nov 2022]. Disponible sur:
https://www.worldgastroenterology.org/UserFiles/file/guidelines/acute-diarrhea-french2012.pdf
Maladies diarréhiques [Internet]. [cité 6 nov 2022]. Disponible sur:
https://www.who.int/fr/news-room/fact-sheets/detail/diarrhoeal-disease
Emina JBO, Kandala NB. Accounting for recent trends in the prevalence of diarrhoea in the Democratic Republic of Congo (DRC): results from consecutive cross-sectional surveys. BMJ Open. 2012;2(6):e001930.
Otsuka Y, Agestika L, Widyarani null, Sintawardani N, Yamauchi T. Risk Factors for Undernutrition and Diarrhea Prevalence in an Urban Slum in Indonesia: Focus on Water, Sanitation, and Hygiene. Am J Trop Med Hyg. mars 2019;100(3):727‑32.
Ullah MB, Mridha MK, Arnold CD, Matias SL, Khan MSA, Siddiqui Z, et al. Factors associated with diarrhea and acute respiratory infection in children under two years of age in rural Bangladesh. BMC Pediatr. 27 oct 2019;19:386.
EBSCOhost | 143525428 | FACTEURS FAVORISANT LES MALADIES DIARRHEIQUES CHEZ LES ENFANTS DE 0 à 5 ANS EN COMMUNE II DU DISTRICT DE BAMAKO-MALI. [Internet]. [cité 1 nov
. Disponible sur:
https://web.p.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=cra wler&jrnl=04647874&AN=143525428&h=GVCrZtxpP92Of67kE6ZNA2xsLIMGZH%2b2R4FDuc2FFAh HCSacKi%2bagJPbFMLGjsfn8qS8xuxPvnyrOGCwuZvw%2fQ%3d%3d&crl=c&resultNs=AdminWe bAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost
%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d04647874%26AN%3d143525428
Zegeye B, Keetile M, Ahinkorah BO, Ameyaw EK, Seidu AA, Yaya S. Association between
Attitude towards Wife Beating and Childhood Diarrhea: A Demographic and Health SurveyBased Study in 25 Sub-Saharan African Countries. ScientificWorldJournal. 2021;2021:4870994.
Reiner RC, Graetz N, Casey DC, Troeger C, Garcia GM, Mosser JF, et al. Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000–2015. N Engl J Med. 20 sept 2018;379(12):1128‑38.
Sangaji MK, Mukuku O, Mutombo AM, Mawaw PM, Swana EK, Kabulo BK, et al.
[Epidemiological and clinical study of rotavirus acute diarrhea in infants at the hospital Jason Sendwe Lubumbashi, Democratic Republic of Congo]. Pan Afr Med J. 2015;21:113.
Carré D. Conduite à tenir devant une diarrhée aiguë. Étiologies. EMC - Chirurgie. oct 2004;1(5):493‑532.
Scribd [Internet]. [cité 25 juin 2023]. EMC GASTRO-ENTÉROLOGIE Mise À Jour I 2020 PDF |
PDF | Virus | Adenoviridae. Disponible sur: https://fr.scribd.com/document/446268051/EMC-
GASTRO-ENTEROLOGIE-Mise-a-jour-I-2020-pdf
Mado SM, Giwa FJ, Abdullahi SM, Alfa AM, Yaqub Y, Usman Y, et al. Prevalence and Characteristics of Rotavirus Acute Gastroenteritis among Under-five Children in Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. Ann Afr Med. 2022;21(3):283‑7.
Tate JE, Burton AH, Boschi-Pinto C, Parashar UD, World Health Organization–Coordinated
Global Rotavirus Surveillance Network. Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000-2013. Clin Infect Dis. 1 mai 2016;62 Suppl 2:S96‑105.
4. Peck M, Gacic-Dobo M, Diallo MS, Nedelec Y, Sodha SV, Wallace AS. Couverture vaccinale systématique mondiale, 2018. MMWR Morb Mortal Wkly Rep. 2019;68(42):937–42. Correction publiée dans MMWR Morb Mortal Wkly Rep. 2019;68(44):1010 - Recherche Google
[Internet]. [cité 25 juin 2023]. Disponible sur:
https://www.google.com/search?q=4.+Peck+M%2C+Gacic-
Dobo+M%2C+Diallo+MS%2C+Nedelec+Y%2C+Sodha+SV%2C+Wallace+AS.+Couverture+vac cinale+syst%C3%A9matique+mondiale%2C+2018.+MMWR+Morb+Mortal+Wkly+Rep.+2019%3B 68(42)%3A937%E2%80%9342.+Correction+publi%C3%A9e+dans+MMWR+Morb+Mortal+Wkly+R ep.+2019%3B68(44)%3A1010&rlz=1C1ONGR_frCD1028CD1028&oq=4.%09Peck+M%2C+GacicDobo+M%2C+Diallo+MS%2C+Nedelec+Y%2C+Sodha+SV%2C+Wallace+AS.+Couverture+vac cinale+syst%C3%A9matique+mondiale%2C+2018.+MMWR+Morb+Mortal+Wkly+Rep.+2019%3B 68(42)%3A937%E2%80%9342.+Correction+publi%C3%A9e+dans+MMWR+Morb+Mortal+Wkly+R ep.+2019%3B68(44)%3A1010&aqs=chrome..69i57.574795011j0j15&sourceid=chrome&ie=UTF-8
Karampatsas K, Osborne L, Seah ML, Tong CYW, Prendergast AJ. Clinical characteristics and complications of rotavirus gastroenteritis in children in east London: A retrospective casecontrol study. PLoS One. 2018;13(3):e0194009.
VIRUS_ROTAVIRUS.pdf [Internet]. [cité 20 déc 2022]. Disponible sur: https://www.sfmmicrobiologie.org/wp-content/uploads/2019/02/VIRUS_ROTAVIRUS.pdf
Hossain MJ, Powell H, Sow SO, Omore R, Roose A, Jones JCM, et al. Clinical and
Epidemiologic Features of Cryptosporidium-Associated Diarrheal Disease Among Young Children Living in Sub-Saharan Africa: The Vaccine Impact on Diarrhea in Africa (VIDA) Study. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 4 avr 2023;76(Suppl 1):S97.
Rotavirus vaccines:an update. Wkly Epidemiol Rec. 18 déc 2009;84(50):533‑40.
Burnett E, Parashar UD, Tate JE. Global impact of rotavirus vaccination on diarrhea hospitalizations and deaths among children <5 years old: 2006–2019. J Infect Dis. 13 oct 2020;222(10):1731‑9.
Skansberg A, Sauer M, Tan M, Santosham M, Jennings MC. Product review of the rotavirus vaccines ROTASIIL, ROTAVAC, and Rotavin-M1. Hum Vaccin Immunother. 17(4):1223‑34.
Luhata Lungayo C, Burke RM, Cikomola A, Mukamba E, Burnett E, Tate JE, et al.
Epidemiology and pre-vaccine burden of rotavirus diarrhea in Democratic Republic of Congo (DRC): Results of sentinel surveillance, 2009–2019. Vaccine. 29 sept 2022;40(41):5933‑41.
Pukuta ES, Esona MD, Nkongolo A, Seheri M, Makasi M, Nyembwe M, et al. Molecular Surveillance of Rotavirus Infection in the Democratic Republic of the Congo August 2009 to June 2012. Pediatr Infect Dis J. avr 2014;33(4):355‑9.
Luhata Lungayo C, Burke RM, Cikomola A, Mukamba E, Burnett E, Tate JE, et al. Epidemiology and pre-vaccine burden of rotavirus diarrhea in Democratic Republic of Congo (DRC): Results of sentinel surveillance, 2009–2019. Vaccine. 29 sept 2022;40(41):5933‑41.
Kabayiza JC, Nilsson S, Andersson M. Rotavirus infections and their genotype distribution in Rwanda before and after the introduction of rotavirus vaccination. PLoS One. 25 avr 2023;18(4):e0284934.
Gbebangi-Manzemu D, Kampunzu VM, Vanzwa HM, Mumbere M, Bukaka GM, Likele BB, et al. Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study. BMC Pediatrics. 24 avr 2023;23(1):193.
Koukou DM, Michos A, Chatzichristou P, Trimis G, Tatsi EB, Dellis C, et al. Rotavirus epidemiology and genotype distribution in hospitalised children, Greece, 2008 to 2020: A prospective multicentre study. Eurosurveillance. 24 nov 2022;27(47):2101133.
Becker-Dreps S, Meléndez M, Liu L, Enrique Zambrana L, Paniagua M, Weber DJ, et al. Community Diarrhea Incidence Before and After Rotavirus Vaccine Introduction in Nicaragua. Am J Trop Med Hyg. 7 août 2013;89(2):246‑50.
Muendo C, Laving A, Kumar R, Osano B, Egondi T, Njuguna P. Prevalence of rotavirus infection among children with acute diarrhoea after rotavirus vaccine introduction in Kenya, a hospital cross-sectional study. BMC Pediatr. 11 oct 2018;18:323.
Digwo D, Chidebelu P, Ugwu K, Adediji A, Farkas K, Chigor V. Prevalence and relative risk of Rotavirus Gastroenteritis in children under five years in Nigeria: a systematic review and meta-analysis. Pathog Glob Health. 117(1):24‑35.
Fischer TK, Viboud C, Parashar U, Malek M, Steiner C, Glass R, et al. Hospitalizations and
Deaths from Diarrhea and Rotavirus among Children <5 Years of Age in the United States, 1993– 2003. The Journal of Infectious Diseases. 15 avr 2007;195(8):1117‑25.
Digwo D, Chidebelu P, Ugwu K, Adediji A, Farkas K, Chigor V. Prevalence and relative risk of Rotavirus Gastroenteritis in children under five years in Nigeria: a systematic review and meta-analysis. Pathog Glob Health. 117(1):24‑35.
Muendo C, Laving A, Kumar R, Osano B, Egondi T, Njuguna P. Prevalence of rotavirus infection among children with acute diarrhoea after rotavirus vaccine introduction in Kenya, a hospital cross-sectional study. BMC Pediatr. 11 oct 2018;18:323.
Burnett E, Jonesteller CL, Tate JE, Yen C, Parashar UD. Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality from Diarrhea. J Infect Dis. 1 juin 2017;215(11):1666‑72.
Igwe D, Oshun P, Osuagwu C, Efunshile A, Oduyebo O. Prevalence and risk factors of acute gastroenteritis caused by Rotavirus among children in tertiary hospitals, southeastern Nigeria. African Journal of Clinical and Experimental Microbiology. 1 févr 2022;23(1):83‑8.
Godfrey O, Zhang W, Amponsem-Boateng C, Bonney Oppong T, Zhao Q, Li D. Evidence of rotavirus vaccine impact in sub-Saharan Africa: Systematic review and meta-analysis. PLoS One. 27 avr 2020;15(4):e0232113.
Mukaratirwa A, Berejena C, Nziramasanga P, Ticklay I, Gonah A, Nathoo K, et al. Distribution of rotavirus genotypes associated with acute diarrhoea in Zimbabwean children less than five years old before and after rotavirus vaccine introduction. Vaccine. 12 nov 2018;36(47):7248‑55.
Agbla JM, Esona MD, Agbankpe AJ, Capo-Chichi A, Gautam R, Dougnon TV, et al. Molecular characteristics of rotavirus genotypes circulating in the south of Benin, 2016-2018. BMC Res Notes. 19 oct 2020;13(1):485.
Matthijnssens J, Bilcke J, Ciarlet M, Martella V, Bányai K, Rahman M, et al. Rotavirus disease and vaccination: impact on genotype diversity. Future Microbiol. déc 2009;4(10):1303‑16.
Rahman M, Matthijnssens J, Yang X, Delbeke T, Arijs I, Taniguchi K, et al. Evolutionary history and global spread of the emerging g12 human rotaviruses. J Virol. mars 2007;81(5):2382‑90.
Roczo-Farkas S, Kirkwood CD, Cowley D, Barnes GL, Bishop RF, Bogdanovic-Sakran N, et al. The Impact of Rotavirus Vaccines on Genotype Diversity: A Comprehensive Analysis of 2 Decades of Australian Surveillance Data. J Infect Dis. 13 juill 2018;218(4):546‑54.
Kabayiza JC, Nilsson S, Andersson M. Rotavirus infections and their genotype distribution in Rwanda before and after the introduction of rotavirus vaccination. PLoS One. 25 avr 2023;18(4):e0284934.
Simwaka JC, Mpabalwani EM, Seheri M, Peenze I, Monze M, Matapo B, et al. Diversity of rotavirus strains circulating in children under five years of age who presented with acute gastroenteritis before and after rotavirus vaccine introduction, University Teaching Hospital, Lusaka, Zambia, 2008–2015. Vaccine. 12 nov 2018;36(47):7243‑7.
