Facteurs associés à la morbi-mortalité maternelle et périnatale chez les accouchées d’au moins 35 ans aux Cliniques Universitaires de Lubumbashi de 2021 à 2022
Mots-clés :
Childbirth, elderly woman, frequency, morbidity and mortality, University Clinics of Lubumbashi, Accouchement, femme âgée, fréquence, morbi-mortalité, Cliniques Universitaires de LubumbashiRésumé
Introduction
L’étude avait pour objectifs de déterminer la fréquence des accouchements chez les gestantes âgées d’au moins 35 ans ; décrire leurs caractéristiques sociodémographiques ; identifier et évaluer le risque de morbi-mortalité maternelle et périnatale chez ces femmes comparativement aux femmes âgées de 20 à 34 ans.
Matériels et Méthodes : Une étude descriptive et analytique cas – témoins était réalisée aux Cliniques Universitaires de Lubumbashi du 01 Janvier 2021 au 30 Juin 2022 avec un échantillon exhaustif et de commodité incluant 215 cas contre 215 témoins. Les tests de Chi-carré et t de Student ont été utilisés pour comparer respectivement les proportions et les moyennes, la régression logistique pour l’analyse multivariée ainsi que l’OR et son IC à 95 % pour évaluer le niveau d’association entre variables. Le seuil de signification a été fixé à p < 0,05.
Résultats : La fréquence des accouchements des gestantes âgées de 35 ans et plus était de 7,46%. Les gestantes âgées de 35 ans et plus étaient multipares et grandes multipares (p<0,0001). La morbidité maternelle chez les cas était caractérisée par un risque significativement plus élevé d’hématome rétro placentaire (ORa=7,9 [1,7–36,7]), d’utilisation d’ocytocine (ORa=3,4 [2,1–5,3]) et d’induction du travail (ORa=3,6 [1,8 – 7,3]). Le décès périnatal (ORa=5,1 [1,1–22,8]) était significativement plus associé à l’âge maternel ≥35 ans.
Conclusion : L’accouchement de la femme âgée est assez fréquent à Lubumbashi, et présente un risque important de morbi-mortalité maternelle et périnatale, méritant de ce fait une attention et une prise en charge appropriées.
ABSTRACT
Introduction: The objectives of our study were to: determine the frequency of childbirth among pregnant women aged 35 and over; describe the socio-demographic characteristics of the mothers concerned; and identify the risk factors associated with maternal and perinatal morbidity and mortality compared to women aged 20 to 34 years.
Materials and methods: A descriptive case-control study was carried out at the University Clinics of Lubumbashi from January 01, 2021 to June 30, 2022 with an exhaustive study sample of convenience systematically including 215 cases against 215 controls. The following statistical tests and estimates were used: Chi-square and Student's t tests to compare the proportions and means respectively, logistic regression for the multivariate analysis as well as the OR and its 95% CI to evaluate the level of association between variables. The significance level was set at p < 0.05.
Results: The childbirths frequency of pregnant women aged 35 and over was 7.46%. Pregnant women aged 35 and over were multiparous and grand multiparous (p<0.0001). Maternal morbidity and mortality in the study group, compared to pregnant women aged 20 to 34, was characterized by a significantly higher risk of retroplacental hematoma (aOR=7.9 [1.7–36.7]), use of oxytocin (aOR=3.4 [2.1–5.3]) and induction of labor (aOR=3.6 [1.8–7.3]). Regarding perinatal morbidity and mortality, perinatal death (aOR=5.1 [1.1–22.8]) was significantly more associated with maternal age ≥35 years.
Conclusion: The childbirth of the elderly woman is quite frequent in Lubumbashi, presents a significant risk of maternal and perinatal morbidity and mortality, thus deserving of attention and appropriate care.
Téléchargements
Références
Salem KB, Mhamdi SE, Amor IB, SRIHA A, LETAIEF M, SOLTANI MS. Caracteristiques epidemiologiques et chronologiques des parturientes aux ages extremes dans la región de Monastir entre 1994-2003. Tunis Médicale 2010; 88:563–8.
Montan S. Increased risk in the elderly parturient. Curr Opin Obstet Gynecol 2007; 19:110–2. https://doi.org/10.1097/GCO.0b013e3280825603.
Treffers PE. Teenage pregnancy, a worldwide problem. Ned Tijdschr Geneeskd 2003;147:2320–5.
Vincent-Rohfritsch A, Le Ray C, Anselem O, Cabrol D, Goffinet F. Grossesse à 43 ans et plus: risques maternels et périnataux. Rev Sage-Femme 2012; 11:226–33.
Lesage S, Mercier FJ. Parturiente âgée (podcast). Prat En Anesth Réanimation 2014;18:164–9.
Carolan M. Maternal age≥ 45 years and maternal and perinatal outcomes: a review of the evidence. Midwifery 2013; 29:479–89.
Carolan M, Frankowska D. Advanced maternal age and adverse perinatal outcome: a review of the evidence. Midwifery 2011; 27:793–801.
Kenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS. Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PloS One 2013; 8:e56583.
Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel JP, et al. Advanced maternal age and pregnancy outcomes: a multicountry assessment. BJOG Int J Obstet Gynaecol 2014; 121:49–56.
Kakudji YK, Nsambi JB, Mukuku O, Tandu-Umba B, Kakudji PL. Profile of delivering mothers in Lubumbashi, Democratic Republic of Congo. Afr J Health Issues Afr J Health Issues 2017; 1:3.
Kaka JC, Kabakele A, Nkolangi J. Advanced maternal age from birth. Research conducted at the Mother-Child Center of Bumbu in Kinshasa (RD Congo). Médecine Afr Noire 2015;62:277–83.
Bwana K. I. Grossesse et accouchement chez la femme de plus de 35 anss: fréquence et morbi--mortalité foeto--maternelle. Révue Africaine de Médecine et de Santé-Publique. Rev.Afr.Méd & S.P|N°1-Vol.2. Juin 2018. n.d.
Pawde AA, Kulkarni MP, Unni J. Pregnancy in women aged 35 years and above: a prospective observational study. J Obstet Gynecol India 2015; 65:93–6.
Schimmel MS, Bromiker R, Hammerman C, Chertman L, Ioscovich A, Granovsky-Grisaru S, et al. The effects of maternal age and parity on maternal and neonatal outcome. Arch Gynecol Obstet 2015; 291:793–8.
Dulitzki M, Soriano D, Schiff E, Chetrit A, Mashiach S, Seidman DS. Effect of very advanced maternal age on pregnancy outcome and rate of cesarean delivery. Obstet Gynecol 1998;92:935–9.
Rashed HE, Awaluddin Sm, Ahmad NA, Supar NH, Lani Z, Aziz F, et al. Advanced maternal age and adverse pregnancy outcomes in Muar, Johor, Malaysia. Sains Malays 2016; 45:1537–42.
Khalil A, Syngelaki A, Maiz N, Zinevich Y, Nicolaides KH. Maternal age and adverse pregnancy outcome: a cohort study. Ultrasound Obstet Gynecol 2013;42:634–43.
Cooke A, Mills TA, Lavender T. Advanced maternal age: Delayed childbearing is rarely a conscious choice: A qualitative study of women’s views and experiences. Int J Nurs Stud 2012;49:30–9.
Vincent A. Âge maternel très avancé et issues de grossesse : données actuelles 2018.
Belaisch-Allart J. Grossesse et accouchement après 40 ans. Gynecologie/Obstetrique 2008;5:1–8.
Berkowitz GS, Skovron ML, Lapinski RH, Berkowitz RL. Delayed childbearing and the outcome of pregnancy. N Engl J Med 1990;322:659–64.
Jacobsson B., Ladfors L., Milsom I. Advanced maternal age and adverse perinatal outcome. Obstet Gynecol 2004.
Ezra Y, McParland P, Farine D. High delivery intervention rates in nulliparous women over age 35. Eur J Obstet Gynecol Reprod Biol 1995; 62:203–7.
White JA, Wright V, Hudson AM. Relationships between habitual physical activity and osteoarthrosis in ageing women. Public Health 1993; 107:459–70.
Van Katwijk C, Peeters LL. Clinical aspects of pregnancy after the age of 35 years: a review of the literature. Hum Reprod Update 1998; 4:185–94.
Hurley BF. Age, gender, and muscular strength. J Gerontol-Biol Sci Med Sci 1995; 50:41–4.
Smith GCS, Cordeaux Y, White IR, Pasupathy D, Missfelder-Lobos H, Pell JP, et al. The effect of delaying childbirth on primary cesarean section rates. PLoS Med 2008; 5:e144.
Amarin V. Effect of maternal age on pregnancy outcome: a hospital based study. J Med Med Res 2013; 1:28–31.
Ahmed K, Ahmed S, Handady S, Alawad A, Ali S. Advanced maternal age and late pregnancy outcome at Omdurman New Hospital in Sudan. Int J Med 2015; 3:115–7.
Suzuki S, Miyake H. Obstetric outcomes in nulliparous women aged 35 and over with singleton pregnancies conceived by in vitro fertilization. Arch Gynecol Obstet 2008; 277:225–7.
Gribble KE, Jarvis G, Bock M, Mark Welch DB. Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring. Aging Cell 2014; 13:623–30.
Keirse MJ, Hanssens M, Devlieger H. Trends in preterm births in Flanders, Belgium, from 1991 to 2002. Paediatr Perinat Epidemiol 2009; 23:522–32.
Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, Nyberg DA, Comstock CH, et al. Impact of Maternal Age on Obstetric Outcome: Obstet Gynecol 2005;105:983–90. https://doi.org/10.1097/01.AOG.0000158118.75532.51.
Vohr BR, Tyson JE, Wright LL, Perritt RL, Li L, Poole WK, et al. Maternal age, multiple birth, and extremely low birth weight infants. J Pediatr 2009;154:498–503.
Santos GHN dos, Martins M da G, Sousa M da S, Batalha S de JC. Impacto da idade materna sobre os resultados perinatais e via de parto. Rev Bras Ginecol E Obstetrícia 2009; 31:326–34.
Huang L, Sauve R, Birkett N, Fergusson D, van Walraven C. Maternal age and risk of stillbirth: a systematic review. Cmaj 2008; 178:165–72.